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Results Sixty-nine articles were found, among them, only 1 1.

Therefore, it had been demonstrated to have an effect on DNA damage and hepatocarcinogenesis [128].

N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized, placebo-controlled pilot study.

The HBV infection can alter the metabolism of host cells to sustain its replication and expression including the up-regulation of glutamate dehydrogenase 1 and isocitrate dehydrogenase [120], the transcriptional up-regulation of genes involved in lipid biosynthesis [121] and the promotion of both hexosamine and phosphatidylcholine biosynthesis [122].

A common source of OS in liver diseases emanates from activated hepatic phagocytes, the KCs [25], also known as Browicz-Kupffer cells and stellate macrophages [37], one of the resident innate immune cell populations [20].

Concluding Remarks Based on the above discussion and in results listed in Table 2, several remarks can be written, which might lead to some rationalization or design of further studies, challenges and perspectives in the use of NAC in OS-based diseases.

However, a standard experimental design of protection and treatment and the increase of human studies are necessary so that the professionals can be sure about the effectiveness and safety of NAC prescription.

It was originally believed that NAC might have the capability to entering in cell via membranes without aminoacid transporters, due to the reduced charge imparted by the acetyl moiety.

Alternative metabolism of alcohol by CYP2E1 leads to the production of ROS, causing lipid peroxidation and inflammation.

The results related to the supplementation of NAC in any form of administration and type of study are satisfactory in 85.